The First Bioshock took place in Rapture, a city built by Andrew Ryan. You start of the game on an airplane that just crashed out by a lighthouse. Which happens to be the only thing in site. As you walk in the light house and make your way into the city you just found you get helped by Atlas as he helps you find a way to defend yourself. As the game progresses you deal with Big Daddies, protectors of the Little Sisters, along with Little sisters, nicely put enough they collect that adam that isn't in use(corspe looting). After dealing with the big daddy you have a choice of saving or harvesting the Little Sister for Adam. The big diffrence that is made is that by not harvesting them they live allowing you to get the good ending, plus some extra loot along the way. You find out that your the son of Ryan who had been bought as an Embryo and later programmed to do whatever your told after being ask "would you kindly". Eventually you do Kill Andrew Ryan and Atlas reveales he is really Frank Fountain after you stop Rapture from self destructing and then sends security bots to kill you, escapting only thanks to the help of the little sisters. Frank then activate "Code Yellow" which slows your heart rate as a way of killing you, as you are now and threat and of no use to him. The little sisters and Tenenbaum help you find a cure to your precoded responses. After truly freeing yourself you go after Frank who gets himslef so hyped up on Adam he barely looks human. After killing him you you get one of three endings.

Saved all the sisters: You take the little sisters out of rapture after refusing the key to the city along with Jack is in his death bed and the little sisters have grown up and lived their lives. Get married, go to college and start a family of their own.

Harvest the little sisters:

You take control of the city almost by force it shows a submarie that comes near the lighthouse and watch the entire crew to get murdered.

Decided to save and harvest some: Same as the good ending but with a sadder undertone  

You start out being revieved from the dead, as you later find out the little girl that was your your little sister before you were hypnotised and forced to commit suicide, which also happens infront of your little sister. It is later revieled that it is your little sister from trouble. As you fight your way through the ruins you have to protect the little sisters as they harvest adam from bodies, you can harvest them when you find them but harvesting after they collect is worth more. At the end of each level when all the little Sisters are dealt with you run into Big Sisters. They are fast mean and pissed off that you have freed or gotten rid of the little sisters under their control, you are given a warning and set things up for the confrontation. Eventually you do find and meet up with you original little sister who is killed, for a second, by her mother ultimately criplying you so that your slowly dying as a side effect of the loss of the connectiong with your little sister. At this point you see yourself laying on a table as Sofia took advantage of you being down at this point your allowed to take control of a little sister going through the vents and seeing the world through their eyes. The decay and distruction becomes beutiful art work as the dead bodies look like sleeping angels, you need to harvest them so you can get ready for the final fight along with collecting gear to let Eleanor becomes a big sister, which are seen as fancy clothing. After you regain control of Delta and make your escape from rapture which is almost stoped by explosive charges going off. You both make it to the escape pod but only Eleanor is able to teliport inside and Delta grabs and hangs onto the outside as it goes to teh surface, from his wounds and shattered bonds Delta is breathing his dying breaths, he either becomes preserved in Elinor through his Adam being Extracted or he pushes away the needle and dies. If your adam is extracted you see the world through Eleanors eyes.