This years E3 is in about a months time. So it's time to make predictions on what will appear. (General Gaming cause this doesn't have to necessarily be Nintendo predictions)

Half-Life 3
Half-Life 2: Episode 3
Final Fantasy Versus XIII

Fire Emblem: Awakening
Super Smash Bros 4
More Wii U details + games
Professor Layton and the Mask of Miracle
Professor Layton vs Ace Attorney
Project X Zone
Pandora's Tower
Dragon Quest X

This is less of a prediction and more so a complete guess without any sort of knowledge to backup my guess:

Valve will announce Portal 3 then release it 9 years later.

Two games in my mind, and both are incredibly awesome; Assassin's Creed III and God of War Ascension!

I'm pretty a sure we will get a trailer for SSB4.

Other then that there's no telling what can happen.

Killer instinct 3 and SSB4

I think this E3 will be a string of disappointments especially with regards to the next home consoles. As for games, I hold out hope for something unexpected for PC and/or localization confirmations for 3DS games.

E3 is usually the time where game industries say "Hey, look at all of this neat stuff! Half of it won't see release and the other half will be plagued with delays!"

I am looking forward to some B2W2 info, and possibly Pikmin 3.

And maybe a video game version of The Wall with a gameplay format similar to that of Heavy Rain but that's like the most off-The-Wall idea ever

Assassin Creed III and Black Ops II

yes, i did mention CoD in here. you msy think it sucks, but thats just like your opinion, man

Im hoping to see KH3 (Kingdom hearts 3) to be shown, ive been waiting for years for the 3rd game to come out even though million others feel the same way. My mom was hoping pikmin 3 will be out soon she loves pikmin.

I know no one else is interested, but I'm expecting a Forza Horizon trailer. I know how Turn10 does their crap. They let out a couple trailers at major events, and then give you absolutely nothing else until it's released a few months later.